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Dr. Tae-Hee Lee of Penn State University will be presenting a seminar titled Single Molecule Studies of Nucleosome Structure and Dynamics.

Abstract: The nucleosome is the fundamental packing unit of the eukaryotic genome. The structure and structural dynamics of the nucleosome are at the core of the mechanisms of gene regulation and maintenance. We studied the structure, structural dynamics, and assembly of nucleosome core particles and how these properties are altered by various epigenetic modifications based on single molecule fluorescence measurements. Our study revealed that these modifications induce changes in the nucleosome core particles that may directly or indirectly contribute to gene regulation activities. Our study demonstrates how single molecule methods can fill the niche not covered by the conventional structural biology tools.

Refreshments will be served at this event.

Faculty Host:  Dr. Chris Richards