The effect of an adenosine A<sub>2A</sub> agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma.
| Author | |
|---|---|
| Abstract |
:
The blood-brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A2A receptors causes transient BBB disruption and increased drug concentrations in normal brain. This study was conducted to evaluate if activation of A2A receptors would increase intra-tumoral temozolomide concentrations in patients with glioblastoma. |
| Year of Publication |
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2018
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| Journal |
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Fluids and barriers of the CNS
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| Volume |
:
15
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| Issue |
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1
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| Number of Pages |
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2
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| Date Published |
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2018
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| URL |
:
https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-017-0088-8
|
| DOI |
:
10.1186/s12987-017-0088-8
|
| Short Title |
:
Fluids Barriers CNS
|
| Download citation |
