Latinxs have the highest prevalence of obesity in the United States, which can further contribute to the pervasive disparities in morbidity and mortality. Although the experience of discrimination is associated with obesity in racial/ethnic minorities, mediators and moderators of this association, specifically among Latinx emerging adults, have been understudied. The present study investigated an individual-level mediator (eating disorder symptoms) and cultural moderators (familismo support, ethnic identity affirmation) of the association between perceived discrimination and body mass index (BMI) among Latinx emerging adults.