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The genetic implication of scoliosis in osteogenesis imperfecta: a review.

Author
Abstract
:

Osteogenesis imperfecta (OI) is a kind of heritable connective tissue disorder, including blue sclerae, hearing loss, skeletal dysplasia causing bone fragility and deformities. It is typically caused by collagen related gene mutations, which could lead to bone formation abnormalities. Scoliosis is one of the most common and severe spinal phenotype which has been reported in approximately 26-74.5% of all OI patients. Recent breakthroughs have suggested that OI can be divided into more than 16 types based on genetic mutations with different degrees of scoliosis. In this review, we summarize the etiology of scoliosis in OI, especially the genetic studies of different types. We aim to provide a systematic review of the genetic etiology and clinical suggestions of scoliosis in OI.

Year of Publication
:
2017
Journal
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Journal of spine surgery (Hong Kong)
Volume
:
3
Issue
:
4
Number of Pages
:
666-678
ISSN Number
:
2414-469X
URL
:
http://dx.doi.org/10.21037/jss.2017.10.01
DOI
:
10.21037/jss.2017.10.01
Short Title
:
J Spine Surg
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