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Anne-Frances Miller

Research Interests:
Enzymes
redox catalysis
flavin-mediated reactions
flavin redox
and photochemistry
enzyme-functionalized electrodes and membranes
spectroscopy
mechanistic enzymology
enzyme engineering
Education
  • Ph.D Yale University, 1989
  • Postdoctoral, Massachusetts Institute of Technology, 1989-90
  • Postdoctoral Fellow, Brandeis Univ. 1990-92
Research
Graduate Training

Bioinorganic Chemistry, Spectroscopy, Biochemistry

PubMed Publications*: 
  • N Mohamed-Raseek; AF Miller"Contrasting roles for two conserved arginines: Stabilizing flavin semiquinone or quaternary structure, in bifurcating electron transfer flavoproteins."The Journal of biological chemistry298.4(2022):101733.Details. Full text
  • RK Kar; S Chasen; MA Mroginski; AF Miller"Tuning the Quantum Chemical Properties of Flavins via Modification at C8."The journal of physical chemistry. B125.46(2021):12654-12669.Details. Full text
  • TA Varner; N Mohamed-Raseek; AF Miller"Assignments of <sup>19</sup>F NMR resonances and exploration of dynamics in a long-chain flavodoxin."Archives of biochemistry and biophysics703.(2021):108839.Details. Full text
  • HD Duan; SA Khan; AF Miller"Photogeneration and reactivity of flavin anionic semiquinone in a bifurcating electron transfer flavoprotein."Biochimica et biophysica acta. Bioenergetics1862.7(2021):148415.Details. Full text
  • W Pitsawong; P Chenprakhon; T Dhammaraj; D Medhanavyn; J Sucharitakul; C Tongsook; WJH van Berkel; P Chaiyen; AF Miller"Tuning of p<i>K<sub>a</sub></i> values activates substrates in flavin-dependent aromatic hydroxylases."The Journal of biological chemistry295.12(2020):3965-3981.Details. Full text
  • HD Duan; N Mohamed-Raseek; AF Miller"Spectroscopic evidence for direct flavin-flavin contact in a bifurcating electron transfer flavoprotein."The Journal of biological chemistry295.36(2020):12618-12634.Details. Full text
  • GJ Schut; N Mohamed-Raseek; M Tokmina-Lukaszewska; DW Mulder; DMN Nguyen; GL Lipscomb; JP Hoben; A Patterson; CE Lubner; PW King; JW Peters; B Bothner; AF Miller; MWW Adams"The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>."The Journal of biological chemistry294.9(2019):3271-3283.Details. Full text
  • GJ Schut; N Mohamed-Raseek; M Tokmina-Lukaszewska; DW Mulder; DMN Nguyen; GL Lipscomb; JP Hoben; A Patterson; CE Lubner; PW King; JW Peters; B Bothner; AF Miller; MWW Adams"The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD&lt;sup/&gt;."The Journal of biological chemistry294.9(2019):3271-3283.Details. Full text
  • N Mohamed-Raseek; HD Duan; P Hildebrandt; MA Mroginski; AF Miller"Spectroscopic, thermodynamic and computational evidence of the locations of the FADs in the nitrogen fixation-associated electron transfer flavoprotein."Chemical science10.33(2019):7762-7772.Details. Full text
  • AF Miller; JT Park; KL Ferguson; W Pitsawong; AS Bommarius"Informing Efforts to Develop Nitroreductase for Amine Production."Molecules (Basel, Switzerland)23.2(2018):Details. Full text
  • HD Duan; CE Lubner; M Tokmina-Lukaszewska; GH Gauss; B Bothner; PW King; JW Peters; AF Miller"Distinct properties underlie flavin-based electron bifurcation in a novel electron transfer flavoprotein FixAB from <i>Rhodopseudomonas palustris</i>."The Journal of biological chemistry293.13(2018):4688-4701.Details. Full text
  • AM Costas; S Poudel; AF Miller; GJ Schut; RN Ledbetter; KR Fixen; LC Seefeldt; MWW Adams; CS Harwood; ES Boyd; JW Peters"Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family."Journal of bacteriology199.21(2017):Details. Full text
  • RN Ledbetter; AM Costas; CE Lubner; DW Mulder; M Tokmina-Lukaszewska; JH Artz; A Patterson; TS Magnuson; ZJ Jay; HD Duan; J Miller; MH Plunkett; JP Hoben; BM Barney; RP Carlson; AF Miller; B Bothner; PW King; JW Peters; LC Seefeldt"The Electron Bifurcating FixABCX Protein Complex from Azotobacter vinelandii: Generation of Low-Potential Reducing Equivalents for Nitrogenase Catalysis."Biochemistry56.32(2017):4177-4190.Details. Full text
  • AF Miller; T Wang"A Single Outer-Sphere Mutation Stabilizes apo-Mn Superoxide Dismutase by 35 °C and Disfavors Mn Binding."Biochemistry56.29(2017):3787-3799.Details. Full text
  • JP Hoben; CE Lubner; MW Ratzloff; GJ Schut; DMN Nguyen; KW Hempel; MWW Adams; PW King; AF Miller"Equilibrium and ultrafast kinetic studies manipulating electron transfer: A short-lived flavin semiquinone is not sufficient for electron bifurcation."The Journal of biological chemistry292.34(2017):14039-14049.Details. Full text
  • W Pitsawong; CA Haynes; Koder RL Jr; DW Rodgers; AF Miller"Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase."Structure (London, England : 1993)25.7(2017):978-987.e4.Details. Full text
  • R Sarma; MS Islam; AF Miller; D Bhattacharyya"Layer-by-Layer-Assembled Laccase Enzyme on Stimuli-Responsive Membranes for Chloro-Organics Degradation."ACS applied materials & interfaces9.17(2017):14858-14867.Details. Full text
  • CE Lubner; DP Jennings; DW Mulder; GJ Schut; OA Zadvornyy; JP Hoben; M Tokmina-Lukaszewska; L Berry; DM Nguyen; GL Lipscomb; B Bothner; AK Jones; AF Miller; PW King; MWW Adams; JW Peters"Mechanistic insights into energy conservation by flavin-based electron bifurcation."Nature chemical biology13.6(2017):655-659.Details. Full text
  • S Das; W Xu; HJ Lehmler; AF Miller; BL Knutson; SE Rankin"Inverted Micelle-in-Micelle Configuration in Cationic/Carbohydrate Surfactant Mixtures."Chemphyschem : a European journal of chemical physics and physical chemistry18.1(2017):79-86.Details. Full text
  • R Sarma; MJ Sloan; AF Miller"Flavin-sensitized electrode system for oxygen evolution using photo-electrocatalysis."Chemical communications (Cambridge, England)52.57(2016):8834-7.Details. Full text
  • JW Peters; AF Miller; AK Jones; PW King; MW Adams"Electron bifurcation."Current opinion in chemical biology31.(2016):146-52.Details. Full text
  • J Pan; M Bhardwaj; Faulkner JR; P Nagabhyru; ND Charlton; RM Higashi; AF Miller; CA Young; RB Grossman; CL Schardl"Ether bridge formation in loline alkaloid biosynthesis."Phytochemistry98.(2014):60-8.Details. Full text
  • W Pitsawong; JP Hoben; AF Miller"Understanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism."The Journal of biological chemistry289.22(2014):15203-14.Details. Full text
  • S Rathnayake; JM Unrine; J Judy; AF Miller; W Rao; PM Bertsch"Multitechnique investigation of the pH dependence of phosphate induced transformations of ZnO nanoparticles."Environmental science & technology48.9(2014):4757-64.Details. Full text
  • AF Miller"Superoxide dismutases: ancient enzymes and new insights."FEBS letters586.5(2012):585-95.Details. Full text
  • D Cui; RL Koder; PL Dutton; AF Miller"15N solid-state NMR as a probe of flavin H-bonding."The journal of physical chemistry. B115.24(2011):7788-98.Details. Full text
  • B Purushothaman; M Bruzek; Parkin SR; AF Miller; JE Anthony"Synthesis and structural characterization of crystalline nonacenes."Angewandte Chemie (International ed. in English)50.31(2011):7013-7.Details. Full text
  • JW Johnston; H Shamsulddin; AF Miller; MA Apicella"Sialic acid transport and catabolism are cooperatively regulated by SiaR and CRP in nontypeable Haemophilus influenzae."BMC microbiology10.(2010):240.Details. Full text
  • AF Miller; E Yikilmaz; S Vathyam"15N-NMR characterization of His residues in and around the active site of FeSOD."Biochimica et biophysica acta1804.2(2010):275-84.Details. Full text
  • AF Miller"The shortest wire."Proceedings of the National Academy of Sciences of the United States of America105.21(2008):7341-2.Details. Full text
  • WL Boatright; MS Jahan; BM Walters; AF Miller; D Cui; EJ Hustedt; Q Lei"Carbon-centered radicals in isolated soy proteins."Journal of food science73.3(2008):C222-6.Details. Full text
  • AF Miller"Redox tuning over almost 1 V in a structurally conserved active site: lessons from Fe-containing superoxide dismutase."Accounts of chemical research41.4(2008):501-10.Details. Full text
  • E Yikilmaz; J Porta; LE Grove; A Vahedi-Faridi; Y Bronshteyn; TC Brunold; GE Borgstahl; AF Miller"How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts?"Journal of the American Chemical Society129.32(2007):9927-40.Details. Full text
  • Koder RL Jr; JD Walsh; MS Pometun; PL Dutton; RJ Wittebort; AF Miller"15N solid-state NMR provides a sensitive probe of oxidized flavin reactive sites."Journal of the American Chemical Society128.47(2006):15200-8.Details. Full text
  • E Yikilmaz; DW Rodgers; AF Miller"The crucial importance of chemistry in the structure-function link: manipulating hydrogen bonding in iron-containing superoxide dismutase."Biochemistry45.4(2006):1151-61.Details. Full text
  • BW Chellgren; AF Miller; TP Creamer"Evidence for polyproline II helical structure in short polyglutamine tracts."Journal of molecular biology361.2(2006):362-71.Details. Full text
  • AF Miller"Superoxide dismutases: active sites that save, but a protein that kills."Current opinion in chemical biology8.2(2004):162-8.Details. Full text
  • AF Miller; K Padmakumar; DL Sorkin; A Karapetian; CK Vance"Proton-coupled electron transfer in Fe-superoxide dismutase and Mn-superoxide dismutase."Journal of inorganic biochemistry93.1-2(2003):71-83.Details. Full text
  • J Maliekal; A Karapetian; C Vance; E Yikilmaz; Q Wu; T Jackson; TC Brunold; TG Spiro; AF Miller"Comparison and contrasts between the active site PKs of Mn-superoxide dismutase and those of Fe-superoxide dismutase."Journal of the American Chemical Society124.50(2002):15064-75.Details. Full text
  • RL Koder; CA Haynes; ME Rodgers; DW Rodgers; AF Miller"Flavin thermodynamics explain the oxygen insensitivity of enteric nitroreductases."Biochemistry41.48(2002):14197-205.Details. Full text
  • E Yikilmaz; J Xie; TC Brunold; AF Miller"Hydrogen-bond-mediated tuning of the redox potential of the non-heme Fe site of superoxide dismutase."Journal of the American Chemical Society124.14(2002):3482-3.Details. Full text
  • CA Haynes; RL Koder; AF Miller; DW Rodgers"Structures of nitroreductase in three states: effects of inhibitor binding and reduction."The Journal of biological chemistry277.13(2002):11513-20.Details. Full text
  • RL Koder; O Oyedele; AF Miller"Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase."Antioxidants & redox signaling3.5(2001):747-55.Details. Full text
  • MA Kelly; BW Chellgren; AL Rucker; JM Troutman; MG Fried; AF Miller; TP Creamer"Host-guest study of left-handed polyproline II helix formation."Biochemistry40.48(2001):14376-83.Details. Full text
  • AL Schwartz; E Yikilmaz; CK Vance; S Vathyam; RL Koder; AF Miller"Mutational and spectroscopic studies of the significance of the active site glutamine to metal ion specificity in superoxide dismutase."Journal of inorganic biochemistry80.3-4(2000):247-56.Details. Full text
  • Adeneye Adejuwon; PA Crooks; Z Fadhel-Albayati; AF Miller; SW Zito; OO Adeyemi; EO Agbaje"Antihyperglycemic profile of erinidine isolated from Hunteria umbellata seed."African journal of traditional, complementary, and alternative medicines : AJTCAM10.2(0):189-202.Details.
  • AF Miller"Solid-state NMR of flavins and flavoproteins."Methods in molecular biology (Clifton, N.J.)1146.(0):307-40.Details. Full text
  • AF Miller; HD Duan; TA Varner; Mohamed Raseek"Reduction midpoint potentials of bifurcating electron transfer flavoproteins."Methods in enzymology620.(0):365-398.Details. Full text
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.