Anne-Frances Miller
Research Interests:
Enzymes
redox catalysis
flavin-mediated reactions
flavin redox
and photochemistry
enzyme-functionalized electrodes and membranes
spectroscopy
mechanistic enzymology
enzyme engineering
Education
- Ph.D Yale University, 1989
- Postdoctoral, Massachusetts Institute of Technology, 1989-90
- Postdoctoral Fellow, Brandeis Univ. 1990-92
Research
- Enzymatic Redox Catalysis
- Publications
Graduate Training
Bioinorganic Chemistry, Spectroscopy, Biochemistry
PubMed Publications*:
- "Contrasting roles for two conserved arginines: Stabilizing flavin semiquinone or quaternary structure, in bifurcating electron transfer flavoproteins."The Journal of biological chemistry298.4(2022):101733.Details. Full text
- "Tuning the Quantum Chemical Properties of Flavins via Modification at C8."The journal of physical chemistry. B125.46(2021):12654-12669.Details. Full text
- "Assignments of <sup>19</sup>F NMR resonances and exploration of dynamics in a long-chain flavodoxin."Archives of biochemistry and biophysics703.(2021):108839.Details. Full text
- "Photogeneration and reactivity of flavin anionic semiquinone in a bifurcating electron transfer flavoprotein."Biochimica et biophysica acta. Bioenergetics1862.7(2021):148415.Details. Full text
- "Tuning of p<i>K<sub>a</sub></i> values activates substrates in flavin-dependent aromatic hydroxylases."The Journal of biological chemistry295.12(2020):3965-3981.Details. Full text
- "Spectroscopic evidence for direct flavin-flavin contact in a bifurcating electron transfer flavoprotein."The Journal of biological chemistry295.36(2020):12618-12634.Details. Full text
- "The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>."The Journal of biological chemistry294.9(2019):3271-3283.Details. Full text
- "The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>."The Journal of biological chemistry294.9(2019):3271-3283.Details. Full text
- "Spectroscopic, thermodynamic and computational evidence of the locations of the FADs in the nitrogen fixation-associated electron transfer flavoprotein."Chemical science10.33(2019):7762-7772.Details. Full text
- "Informing Efforts to Develop Nitroreductase for Amine Production."Molecules (Basel, Switzerland)23.2(2018):Details. Full text
- "Distinct properties underlie flavin-based electron bifurcation in a novel electron transfer flavoprotein FixAB from <i>Rhodopseudomonas palustris</i>."The Journal of biological chemistry293.13(2018):4688-4701.Details. Full text
- "Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family."Journal of bacteriology199.21(2017):Details. Full text
- "The Electron Bifurcating FixABCX Protein Complex from Azotobacter vinelandii: Generation of Low-Potential Reducing Equivalents for Nitrogenase Catalysis."Biochemistry56.32(2017):4177-4190.Details. Full text
- "A Single Outer-Sphere Mutation Stabilizes apo-Mn Superoxide Dismutase by 35 °C and Disfavors Mn Binding."Biochemistry56.29(2017):3787-3799.Details. Full text
- "Equilibrium and ultrafast kinetic studies manipulating electron transfer: A short-lived flavin semiquinone is not sufficient for electron bifurcation."The Journal of biological chemistry292.34(2017):14039-14049.Details. Full text
- "Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase."Structure (London, England : 1993)25.7(2017):978-987.e4.Details. Full text
- "Layer-by-Layer-Assembled Laccase Enzyme on Stimuli-Responsive Membranes for Chloro-Organics Degradation."ACS applied materials & interfaces9.17(2017):14858-14867.Details. Full text
- "Mechanistic insights into energy conservation by flavin-based electron bifurcation."Nature chemical biology13.6(2017):655-659.Details. Full text
- "Inverted Micelle-in-Micelle Configuration in Cationic/Carbohydrate Surfactant Mixtures."Chemphyschem : a European journal of chemical physics and physical chemistry18.1(2017):79-86.Details. Full text
- "Flavin-sensitized electrode system for oxygen evolution using photo-electrocatalysis."Chemical communications (Cambridge, England)52.57(2016):8834-7.Details. Full text
- "Electron bifurcation."Current opinion in chemical biology31.(2016):146-52.Details. Full text
- "Ether bridge formation in loline alkaloid biosynthesis."Phytochemistry98.(2014):60-8.Details. Full text
- "Understanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism."The Journal of biological chemistry289.22(2014):15203-14.Details. Full text
- "Multitechnique investigation of the pH dependence of phosphate induced transformations of ZnO nanoparticles."Environmental science & technology48.9(2014):4757-64.Details. Full text
- "Superoxide dismutases: ancient enzymes and new insights."FEBS letters586.5(2012):585-95.Details. Full text
- "15N solid-state NMR as a probe of flavin H-bonding."The journal of physical chemistry. B115.24(2011):7788-98.Details. Full text
- "Synthesis and structural characterization of crystalline nonacenes."Angewandte Chemie (International ed. in English)50.31(2011):7013-7.Details. Full text
- "Sialic acid transport and catabolism are cooperatively regulated by SiaR and CRP in nontypeable Haemophilus influenzae."BMC microbiology10.(2010):240.Details. Full text
- "15N-NMR characterization of His residues in and around the active site of FeSOD."Biochimica et biophysica acta1804.2(2010):275-84.Details. Full text
- "The shortest wire."Proceedings of the National Academy of Sciences of the United States of America105.21(2008):7341-2.Details. Full text
- "Carbon-centered radicals in isolated soy proteins."Journal of food science73.3(2008):C222-6.Details. Full text
- "Redox tuning over almost 1 V in a structurally conserved active site: lessons from Fe-containing superoxide dismutase."Accounts of chemical research41.4(2008):501-10.Details. Full text
- "How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts?"Journal of the American Chemical Society129.32(2007):9927-40.Details. Full text
- "15N solid-state NMR provides a sensitive probe of oxidized flavin reactive sites."Journal of the American Chemical Society128.47(2006):15200-8.Details. Full text
- "The crucial importance of chemistry in the structure-function link: manipulating hydrogen bonding in iron-containing superoxide dismutase."Biochemistry45.4(2006):1151-61.Details. Full text
- "Evidence for polyproline II helical structure in short polyglutamine tracts."Journal of molecular biology361.2(2006):362-71.Details. Full text
- "Superoxide dismutases: active sites that save, but a protein that kills."Current opinion in chemical biology8.2(2004):162-8.Details. Full text
- "Proton-coupled electron transfer in Fe-superoxide dismutase and Mn-superoxide dismutase."Journal of inorganic biochemistry93.1-2(2003):71-83.Details. Full text
- "Comparison and contrasts between the active site PKs of Mn-superoxide dismutase and those of Fe-superoxide dismutase."Journal of the American Chemical Society124.50(2002):15064-75.Details. Full text
- "Flavin thermodynamics explain the oxygen insensitivity of enteric nitroreductases."Biochemistry41.48(2002):14197-205.Details. Full text
- "Hydrogen-bond-mediated tuning of the redox potential of the non-heme Fe site of superoxide dismutase."Journal of the American Chemical Society124.14(2002):3482-3.Details. Full text
- "Structures of nitroreductase in three states: effects of inhibitor binding and reduction."The Journal of biological chemistry277.13(2002):11513-20.Details. Full text
- "Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase."Antioxidants & redox signaling3.5(2001):747-55.Details. Full text
- "Host-guest study of left-handed polyproline II helix formation."Biochemistry40.48(2001):14376-83.Details. Full text
- "Mutational and spectroscopic studies of the significance of the active site glutamine to metal ion specificity in superoxide dismutase."Journal of inorganic biochemistry80.3-4(2000):247-56.Details. Full text
- "Antihyperglycemic profile of erinidine isolated from Hunteria umbellata seed."African journal of traditional, complementary, and alternative medicines : AJTCAM10.2(0):189-202.Details.
- "Solid-state NMR of flavins and flavoproteins."Methods in molecular biology (Clifton, N.J.)1146.(0):307-40.Details. Full text
- "Reduction midpoint potentials of bifurcating electron transfer flavoproteins."Methods in enzymology620.(0):365-398.Details. Full text
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.